Homocysteine and related problems

Homocystine and Musculoskeletal problems

Elevated levels of the amino acid serum Homocysteine is related to several musculoskeletal problems in addition to risk for atherosclerosis, stroke, myocardial infarction, and possibly Alzheimer’s disease. Complex changes occur in muscles cells and blood vessel lining (endothelium). Hyperhomocysteinemia (increased blood levels of Homocysteine) induces oxidative stress and chronic inflammation. This can interfere with body composition and physical function in middle-aged and older adults. The normal level of blood homocysteine is

References :

1. Kositsawat J, Vogrin S, French C, Gebauer M, Candow DG, Duque G, Kirk B. Relationship Between Plasma Homocysteine and Bone Density, Lean Mass, Muscle Strength and Physical Function in 1480 Middle-Aged and Older Adults: Data from NHANES. Calcif Tissue Int. 2023 Jan;112(1):45-54. doi: 10.1007/s00223-022-01037-0. Epub 2022 Nov 7. PMID: 36344761; PMCID: PMC9813058.
2. Fu L, Wang Y, Hu YQ. Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study. Front Nutr. 2022 Nov 24;9:1048122. doi: 10.3389/fnut.2022.1048122. PMID: 36505230; PMCID: PMC9731309.
3. Mu ZJ, Fu JL, Sun LN, Chan P, Xiu SL. Associations between homocysteine, inflammatory cytokines and sarcopenia in Chinese older adults with type 2 diabetes. BMC Geriatr. 2021;21:692. doi: 10.1186/s12877-021-02622-y.
4. Ates Bulut E, Soysal P, Aydin AE, Dokuzlar O, Kocyigit SE, Isik AT. Vitamin B12 deficiency might be related to sarcopenia in older adults. Exp Gerontol. 2017;95:136–140. doi: 10.1016/j.exger.2017.05.017.
5. Faraci FM. Hyperhomocysteinemia: a million ways to lose control. Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):371-3. doi: 10.1161/01.ATV.0000063607.56590.7F. PMID: 12639825.